Combat acne throughout all 3 stages of acne pathogenesis

aczero acne solution

How does acne form? How to remove it?

Aczero

Acne is a common inflammatory skin disease that affects the pilosebaceous units of the skin. Without proper treatment, patients may suffer from severe skin scarring. Therefore, it has been researched extensively to develop potential treatment options.

Acne develops in 3 steps:

types of acne formation and process

Step 1: High concentrations of sebum and keratinous material cause clogging of pores and in turn result in the formation of black and whitehead comedones.

Step 2:  Whitehead and blackhead comedones are anaerobic, lipid-rich environments that are conducive for Propionibacterium acnes proliferation.

Step 3: Bacterial colonization stimulates the generation of chemotactic agents which leads to the formation of inflammatory lesions like papules, pustules and nodules or cysts.

Combination therapy that targets multiple acne development stages simultaneously has been receiving considerable attention due to its higher efficacy compared to monotherapy. MahaChem provides a natural anti-acne solution, ACZERO that targets all 3 stages of acne pathogenesis. Continue reading to find out more!

Our Solution: ACZERO

ACZERO is a natural solution for acne that comprises of 7 plant extracts:

INCI NAME FUNCTION
Salix Alba (Willow) Bark Extract Anti-inflammatory
Camellia Sinensis Leaf Extract Anti-inflammatory, Anti-oxidative
Centella Asiatica Leaf Extract Anti-oxidative, Anti-microbial
Cladosiphon Okamuranus Extract Anti-microbial
Coffea Arabica (Coffee) Seed Extract Anti-oxidative
Citrus Aurantium Bergamia
(Bergamot) Leaf Extract
Anti-inflammatory
Pinus Densiflora Leaf Extract Anti-microbial

What is so special about ACZERO?

  • Patented in Korea
  • Contains 7 plant extracts in optimal amounts to maximize the efficacy of acne treatment
  • Targets acne throughout its pathogenesis with a 3-step acne inhibition mechanism
  • Results in 4 weeks with low dosage used (2%)

ACZERO’s Anti-Acne Mechanism

acne inhibition mechanism

Step 1: Inhibit proliferation of sebocytes, suppressing sebum production (Sebocytes are highly specialized, sebum-producing epithelial cells)

Step 2: Prevents bacterial colonization by inhibiting P.acne activity.

Step 3: Suppress inflammation by reducing inflammatory cytokine, IL-6 production.

Test and Studies on ACZERO

In-vitro tests proved that ACZERO is able to inhibit the proliferation of sebocytes and has higher efficacy compared to 13-Cis-retinoic acid which is an extremely effective drug for acne lesions! Furthermore, only 2% of ACZERO is required for significant results!

inhibit sebocyte proliferation on acne prone skin

0.5% of ACZERO is the Minimum Inhibitory Concentration (MIC) that prevents visible growth of Propionibacterium acnes.

stop acne growth results

ACZERO is able to suppress inflammation through the reduction of IL-6. IL-6 is a pro-inflammatory cytokine that is strongly expressed in sebaceous glands of skin with acne and barely in healthy skin.

aczero reduces skin inflammation

DPPH is used to measure the reducing ability of anti-oxidants towards the DPPH radical. ACZERO is shown to possess anti-oxidative properties.

aczero anti-oxidant property results

According to the toxicity test, the addition of ACZERO has minimal effect on the percentage of cell viability. Thus, ACZERO is non-toxic to human skin.

non-toxic acne solution

In-Vivo Test Results

Further clinical testing on efficacy and safety was performed.

For efficacy testing, an in-vivo test was conducted on 11 participants at a dosage of 2%. As seen below, sebum secretion is reduced significantly.

reduced sebum production-oily skin
reduce sebum production

Patch test was carried out on 31 participants and the results indicate that even with a dosage of 4%, ACZERO will not trigger skin irritation.

non-irritating acne solution

Formulation Guide

Application: Super mild facial wash with natural anti acne solution to prevent microorganism caused acne

Phase Material Function INCI Name Supplier % W/W
A Evermild GLDA-30 Chelating Agent Tetrasodium Glutamate Diacetate Sino Lion 0.1
Deionized Water Solution Water (Aqua) Add to 100
Refined  Glycerine Humectant Glycerine Vance 8
Propylene Glycol Humectant Propylene Glycol Dow Chemical 3
Acecare 30 KC Thickener Acrylate Copolymer KCI 8
B NaOH (aq) pH Adjuster Pottasium Hydroxide, water qs
C Eversoft YCS 30 S Surfactant Sodium Cocoyl Glycinate Sino Lion 5
D Aczero Antimicrobial,Anti oxidant, anti inflammation Salix alba (willow) bark extract, Camellia Sinensis leaf extract, Centella asiatica leaf extract, Cladosiphon Okamuranus extract, Coffe arabica (coffe) seed extract, Citrus aurantium bergamia (Bergamot) leaf extract, Pinus Densiflora extract, Decyl glucoside, 1,2-Hexanediol TEN 1
E Troycare PE 91 Preservative Phenoxyethanol, Ethylhexyl Glycerine Troy 0.8

Procedures

  1. Predisperse phase A in room temperature
  2. Adjust pH to the range 6.5 – 7.5 with NaOH solution
  3. Add phase C and continue mixing until homogeneous
  4. Add phase D & E step by step while mixing

End product appearance

Appearance Gel, Clear-Slightly hazy
pH 6.98
Viscosity, cps 4706.6 mPa.s (25℃, Brookfield RVT, 18rpm, 3#spindle)

Interested to try ACZERO?

Email us for FREE sample now!

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