Freeze dryers (or lyophilizers) are used to process samples for long-term storage or as a sample prep step. Freeze dryers use a combination of refrigeration and vacuum pressure to meet the lyophilization needs of a variety of research and manufacturing environments. In freeze drying, the moisture is taken out by placing the material on racks that are exposed to vacuum. In these vacuum conditions, the temperature is lowered and then slowly raised. This causes the moisture to move from the gaseous state (steam) to solid (frozen). Using the process of sublimation, wherein a sample changes from a solid to a gas, moisture is removed from the sample using heat and a deep vacuum. This vapor is then collected on a cold coil in the form of ice. The most common applications of freeze dryers are Material stabilization and/or storage, Pharmaceuticals, and Food processing.
How many samples are you looking to process?
What type of samples are you processing?
What type of samples will you be processing, and how much liquid do they contain? When choosing a freeze dryer, vendors recommend loading 1/2 of the listed capacity. For example, a 6L freeze dryer will hold 3L during the run.
Last, but not least, where will your freeze dryer be installed?
Do you know your products’ critical temperatures?
What solvents are you using? A temperature differential between the sample’s eutectic temperature and collector temperature of 15–20 degrees is required. If solvents such as acetonitrile are used, a cascade freeze dryer is required.
What Condenser Temperature do you need?
What Chamber Temperature do you need?
What Condenser Capacity do you need?
What type of vacuum pump do you need? If you are working with any acids or solvents, a hybrid or scroll pump is recommended. If you freeze dry solvents or acids with a rotary vane pump and any amount of vapor bypasses the collector, those solvents will wind up in the pump oil and damage the pump. Make sure your pump meets the minimum specifications required to operate your lyophilizer.
Do you need to stopper under vacuum? Accessories can allow you to stopper under vacuum or nitrogen without using compressed gas.
Is this a shared freeze dryer? A hybrid pump is recommended to prevent damage to the pump.
Are there any other accessories you will require?
What level of control automation do you need?
Do you want to freeze dry in flasks, tubes, or bulk? Many drying accessories are available. On a manifold or drying chamber, flasks can be placed on each port. Test tubes and serum vials can be placed inside the flasks for multiple samples per container. If samples are bulk, a tray dryer would be a good choice.
Now that you have a brief introduction to factors to consider when purchasing a freeze dryer. Maha Chemical’s Industrial Solutions together with our partnered brand, Toption, brings you a variety of freeze dryers suitable for your needs.
With a variety of different models to suit your needs, from home-based to both commercial and industrial scale freeze dryers. Allowing you to select one that is suitable for your needs. Maha chem offers different accessories as well, providing a one-stop solution when purchasing Laboratory Equipment. With local service engineers to provide preventive Maintenance, you will not have to worry about a lack of aftersales support!
With variety of different models to suit your needs, from home based to both commercial and industrial scale freeze dryers. Allowing you to select one that suitable for your needs. Maha chem offers the different accessories as well, providing a one stop solution when purchasing Laboratory Equipment. With local service engineers to provide preventive maitainence, you will not have to worry about a lack of aftersales support!
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